Human Trial Shows NMN Enhances Exercise Endurance in Runners

par Eric Francis

Exercise training combined with NMN supplementation increases the endurance performance of middle-aged athletes by improving aerobic capacity.

Highlights

A six-week randomized, double-blind, placebo-controlled 2021 study of amateur runners confirmed these findings in humans:

  • Middle-aged runners, supplementing 600 to 1200 mg/day of NMN for six weeks improved muscle oxygen absorption and increased (VO2max).
  • The muscle oxygen utilization improvements increased with higher NMN doses during endurance exercise.
  • No adverse health effects while taking up to 1200 mg/day of NMN for six weeks were reported.

The human trial was published in the Journal of the International Society of Sports Nutrition showing that NMN taken orally can increase aerobic capacity (the consumption of oxygen by our muscles). 

Combining NMN with Training Improves Endurance Exercise

To determine whether healthy, middle-aged people can reap similar benefits from NMN, Researchers supplemented runners with 300, 600, or 1200 mg/day of orally administered NMN powder for six weeks. During this time, these three dosage groups trained five to six times per week for 40-60 minutes and then underwent heart and lung (cardiopulmonary) exercise testing.

The endurance exercise testing revealed that the body’s ability to absorb oxygen and deliver it to tissues significantly improved with the 600 and 1200 mg/day dosages when compared to runners that didn't take NMN.

By Brett J. Weiss

Published: 12:35 p.m. PST Jul 13, 2021 | Updated: 11:56 am PST Sep 29, 2021

 

For more information about this topic see below:

Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi: 10.1186/s12970-021-00442-4. PMID: 34238308; PMCID: PMC8265078.

https://www.nmn.com/news/human-trial-nmn-enhances-exercise-endurance-runners

https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4

 

 

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