NMN Rejuvenates Stem Cells and Mitochondria

A recent study from Jilin University reveals that nicotinamide mononucleotide (NMN) rejuvenates stem cells and improves mitochondrial function in rats. The research, published in the International Journal of Molecular Sciences, shows that NMN reduces cellular aging and boosts mitochondrial health by activating sirtuin 3 (Sirt3), a longevity-associated protein.

Stem cells have significant potential in regenerative medicine due to their ability to self-renew and heal tissues. However, their efficacy diminishes with cellular senescence—a state of arrested growth. This study found that NMN treatment reduces senescence and increases energy production in old stem cells by enhancing mitochondrial function and decreasing oxidative stress.

Furthermore, NMN’s positive effects on mitochondria were found to depend on Sirt3 activation. When Sirt3 was inhibited, NMN's benefits were reversed, indicating that Sirt3 is crucial for NMN’s action. These findings underscore the potential of NMN in maintaining stem cell function and delaying aging by targeting mitochondrial health.

Benefits of Sirt3 Activation

Sirt3, a critical mitochondrial protein, regulates oxidative stress and ATP production. By boosting Sirt3 activity, NMN helps maintain healthy mitochondria, reducing the burden of senescent cells and enhancing cellular function.

Implications for Longevity

The study highlights the role of sirtuins, particularly Sirt3, in promoting longevity. Sirtuins require NAD+ for activation, making NAD+ precursors like NMN valuable for their health benefits. NMN’s ability to rejuvenate stem cells and mitochondria suggests its potential in anti-aging therapies by activating sirtuins.

Model and Dosage: The study used stem cells from 1-2 month-old male Wistar rats, treated with 100 µM NMN for 48 hours.

Source: Wang H, et al. International Journal of Molecular Sciences, 2022.

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